If our goal is to catch the biggest possible muskie then what we need to do is:
1. find out where the biggest muskies live
2. fish there a lot
3. use good equipment and techniques
I think that the options for where the biggest fish are: the great lakes, the St. Lawrence River, northern Minnesota, and Northwest Ontario.
There are good and bad points about all of them.
One thing not to overlook is how far the spot is from where you live. If it is nearby then you will be inclined to fish it more often.
Finding a likely body of water that you can fish a lot is your first task.